Correlation Between Oral Contraceptives Use and Sexual Activity with Cervical Cancer

Abstract

WHO in 2012 as many as 85% of new cases cervical cancer worldwide occur in developing countries. At 2015, Malang have high cervical cancer case of East Java. The purpose of this study to analyze correlation between oral contraceptives use and sexual activity such as the age of first intercourse, age of first pregnancy and abortion with cervical cancer in poly Obstetrics and Gynecology RSUD Dr. Saiful Anwar Malang. This study use case control design. Populastion in this study is an patient poly Obstetrics and Gynecology RSUD Dr. Saiful Anwar Malang who have check-up in November 2015. The number of cases sampel were 37 patient cervical cancer and control sampel were 111 patient not cervical cancer. This study use systematic random sampling with sampling interval. Data were analyzed using Chi Square with α 5%, OR and 95% CI were used to determine the risk factor. The result of this study did not show significant association of oral contraceptives use with cervical cancer. Age of first sexual intercourse < 18 tahun was p =0,0225147014 (OR 2,3194; 95% CI 1,0854 - 4,9561), Age at first pregnancy < 18 tahun was p =0,0236276656 (OR 2,3388; 95% CI 1,0890 – 5,0230), and abortion was p =0,0038911219 (OR 3,2653; 95% CI 1,4593 – 7,3063) show significant association with cervical cancer. The conclusion of this study oral contraceptives use was not correlation with cervical cancer. The age of first intercourse, age at first pregnancy and abortion have correlation with cervical cancer.Keyword: oral contraceptives use, age of first sexual intercourse, age at first pregnancy, abortion, cervical cancer