Correlation between optical coherence tomography angiography macular parameters with optical coherence tomography structural parameters in primary open angle glaucoma (a longitudinal descriptive study)

Abstract

Background: There is growing evidence indicating that glaucoma pathogenesis is attributed to vascular dysfunction.Aim: compare the macular circulation in normal individuals and glaucomatous patients in the superficial as well as the deep retinal plexuses, to determine and characterize macular circulation deficits in glaucoma along with correlating them with structural macular OCT parameters Methods: descriptive study included 100 eyes of 100 participants who were selected randomly from attendants of ophthalmology outpatient clinic in Beni-suef university hospital Participants were subjected to 24-2 SITA- standard automated VF test using SAP ,OCT ONH examination and OCTA (Macula) Results: IOP showed significant negative moderate to strong linear correlation with all the Macular Parameters in Glaucoma Participants. These correlations were highly significant; (p-values <0.001). All measurements of superficial and deep macular venues plexuses by studied macular OCTA was statistically significantly lower in glaucomatous as compared to non-glaucomatous participants; (p-values <0.001). Conclusion: There was a reduction in VD in particular that of superficial layer in POAG patients in macular region, according to OCTA measurements. Glaucomatous eyes have a significantly sparser superficial VD in the macula when compared to healthy eyes, and these VD assessments are significantly accompanied by the severity of VF destruction and OCT structural affection.