Abstract
BackgroundAcute cerebral infarction (ACI) is seriously harmful to human health worldwide. However, at present, the risk of disease onset is still not accurately predicted for some people.MethodsFive hundred and nineteen patients with ACI and 300 healthy controls were included in this study. We divided the patients into three groups according to the results of cervical artery contrast‐enhanced ultrasound. Ninety‐five patients were in the CAS without plaque group, 108 patients were in the stable plaque group, and 316 patients were in the unstable plaque group. TC, TG, HDL‐C, LDL‐C, and sdLDL‐C were measured in all subjects.ResultsThe level of small dense low‐density lipoprotein cholesterol (sdLDL‐C) in the ACI group was significantly higher than that in the control group (P < 0.001). Logistic regression analysis showed that sdLDL‐C was an independent risk factor for ACI (OR = 1.067, 95% CI: 1.041‐1.093, P < 0.001); serum sdLDL‐C was significantly higher in the unstable plaque group than in the stable plaque group and plaque‐free group (P < 0.05, P < 0.001); serum sdLDL‐C was also higher in the stable plaque group than the plaque‐free group (P < 0.001). Logistic regression analysis showed that sdLDL‐C was an independent risk factor for unstable carotid plaques (OR = 1.053, 95% CI: 1.038‐1.068, P < 0.001); Spearman correlation analysis showed that sdLDL‐C test results were positively correlated with carotid plaque stability (r = 0.363, P < 0.001).ConclusionSmall dense low‐density lipoprotein cholesterol is an independent risk factor for the onset of ACI and may be an early serum marker for this disease.
Highlights
Acute cerebral infarction (ACI) is an ischemic cerebrovascular dis‐ ease that is seriously harmful to human health worldwide
Recent studies have confirmed that small dense low‐density lipoprotein cholesterol (sdLDL‐C) has stronger atherosclerosis ability than low‐density lipoprotein cholesterol (LDL‐C) and has been included in the recently reported important cardiovascular and cerebrovascular disease risk factors by the American Cholesterol Education Program Adult Treatment Group.[5] sdLDL‐C is associated with the number of atherosclerotic plaques and with carotid steno‐ sis caused by atherosclerotic plaque.[6,7]
Despite the significant role of sdLDL‐C in atherosclerosis,[6] whether this relation is consistent with the existing research con‐ clusions, whether sdLDL‐C is related to the stability of Carotid atherosclerosis (CAS) plaque, and whether sdLDL‐C can better predict the risk of ACI have been under studied
Summary
Acute cerebral infarction (ACI) is seriously harmful to human health worldwide. at present, the risk of disease onset is still not accurately pre‐ dicted for some people. Results: The level of small dense low‐density lipoprotein cholesterol (sdLDL‐C) in the ACI group was significantly higher than that in the control group (P < 0.001). Logistic regression analysis showed that sdLDL‐C was an independent risk factor for ACI (OR = 1.067, 95% CI: 1.041‐1.093, P < 0.001); serum sdLDL‐C was significantly higher in the unstable plaque group than in the stable plaque group and plaque‐free group (P < 0.05, P < 0.001); serum sdLDL‐C was higher in the stable plaque group than the plaque‐free group (P < 0.001). Conclusion: Small dense low‐density lipoprotein cholesterol is an independent risk factor for the onset of ACI and may be an early serum marker for this disease. KEYWORDS acute cerebral infarction, small dense low‐density lipoprotein cholesterol, unstable plaque
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