Abstract
Background: NAFLD is an independent risk factor of CKD. CKD prevalences in NAFLD subjects are two times higher than non-NAFLD. The aim of this study is to know the correlation between NAFLD and CKD. Methods: Cross-sectional study was conducted on patients who held Abdominal USG in Wahidin Sudirohusodo & UNHAS hospital from January to December 2017. NAFLD subjects are male and female (18-60 years) who met NAFLD criteria and wanted to participate, non-NAFLD as control subjects. NAFLD is fat accumulation in hepatocyte without a history of alcohol consumption or other etiology of chronic liver disease. CKD definition and classification were based on KDIGO 2012. P value <0.05 was considered to be significant. Results: From the study period, we found 134 subjects (67 NAFLD subjects and 67 non-NAFLD subjects). Correlation analysis between NAFLD and eGFR showed that NAFLD subjects had more proportion of eGFR <60 ml/min/1.73m2 than non-NAFLD subjects (40.3% vs 16.4%, p=0.002). NAFLD subjects significantly had more proportion of CKD Grade 3 than non-NAFLD subjects (37.3% vs 9%) while non-NAFLD subjects had more proportion of CKD Grade 1 and 2 than NAFLD subjects (56.7% vs 38.8% dan 26.9% vs 20.9%)(p=0.001). Correlation analysis between NAFLD and proteinuria did not show significant results (p=0.051). Conclusion: NAFLD subjects correlated with CKD events compared with non-NAFLD subjects.
Highlights
Chronic Kidney Disease (CKD) is a condition in which structural or functional damage of kidney for >3 months causes implications to the health [1]
The aim of this study is to know the correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) and CKD
CKD definition and classification were based on Kidney Disease Improving Global Outcomes (KDIGO) 2012
Summary
Chronic Kidney Disease (CKD) is a condition in which structural or functional damage of kidney for >3 months causes implications to the health [1]. Subjects with NAFLD showed worse clinical outcomes compared to non-NAFLD subjects in the general population, those with liver fibrosis. Examination of liver fibrosis in NAFLD subjects can provide important information regarding the prognosis of the disease [4]. Studies have shown NAFLD as an independent risk factor and contributes to the development of CKD. The prevalence of CKD in NAFLD subjects is 2x higher (20-55%) compared to non-NAFLD subjects (5-30%), in which damage of renal function was significantly associated with the severity of NASH histological [5]. NAFLD is an independent risk factor of CKD. CKD prevalences in NAFLD subjects are two times higher than non-NAFLD. The aim of this study is to know the correlation between NAFLD and CKD
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