Abstract
Isolated perfused hearts and serosal mast cells (MC) of 2- 6- and 18-month-old spontaneously hypertensive rats (SH) were compared to hearts and MC from Wistar-Kyoto (WKY) rats of the same age for their ability to release nitric oxide (NO). The relationship between histamine release and NO production was also investigated. In hearts and MC of 2-, 6- and 18-month-old SH rats, the production of NO is significantly lower than in hearts or MC of WKY rats of the same age. Concomitantly, the spontaneous release of histamine in cardiac perfusates and MC reactivity to various exocytotic stimuli (compound 48/80, calcium ionophore A 23187) is modified by aging and hypertension.
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