Correlation between Nicotinamide Phosphoribosyl Transferase(NAMPT) level andclinicopathological criteria in colorectal cancer patients

Abstract

Background:Colorectal cancer (CRC) is one of the most common cancers worldwide, with the highest incidence rates western countriesThe 5-year survival rate for a patient diagnosed with stage I or II colorectal cancer, is up to 90%. However, the 5-year survival rate for patients diagnosed with stage IV disease, once the cancer has metastasized to other organs, is only 12%. Aim of the work :is todetect levels of Visfatin,Nitric oxide,Lipid peroxide and Superoxide dismutase in serum of patients with colorectal cancer and compare results with patients with benign colorectal tumor and with control group and detect the relation of each of them to the clinic-pathological criteria colorectal cancer. Patients and methods:This study was performed at Sohag University Hospital from December 2015 to June 2016, eighty-five persons were enrolled the study and divided into three groups. 60 patients with colorectal cancer, 10 patients with begin colorectal tumors all of them were selected from SohagCancer Institute and Sohag University Hospital and 15 healthy persons of matched age and sex without evidence of any cancer (controls). All were matched for age and sex, for each participantcomplete medical history, physical examination, and routine investigations were done.Nicotinamidephosphoribosyltransferase (NAMPT) was measured by Eliza kitsNitric oxide and Superoxide dismutase (SOD) activities level were measured by colorimetry.. Results:The serum levels of visfatinNAMPT,NO and lipid peroxidation products as MDAin patients with benign tumor were significantly higher than healthy controls ,in patients with colorectal cancer the levels is significantly higher than healthy controls and patients with benign tumor (p-value < 0.001), and there is significant relations between levels of NAMPT and the clinicopathologicalcritiria of the cancer ,In contrast the levels of antioxidant enzyme (superoxide dismutase) where altereddecreased in colorectal cancer group , benign lesions group comparing to healthy control group . Conculsion:our study relieved that there is positive relation between level of visfatin and colorectal caneroccurance and cancer clinicopathological criteria . Also our study relievedColorectal carcinogenesis is associated with serious oxidative stress and confirms that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer.