Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital

Abstract

Coronavirus Disease 2019 (COVID-19) has a clinical spectrum that varies from asymptomatic to death. Cytokine storms cause neutrophilia, lymphopenia, and thrombocytopenia at various levels of COVID-19 severity. These three parameters can be studied as markers of inflammation in the form of ratios. This study aims to discover the correlation between NLR & PLR inflammatory markers in determining the severity of COVID-19.An analytical cross-sectional study was carried out on secondary data from 274 subjects collected from the subject's hematological parameters from first day of admission to Hasan Sadikin Hospital from May-December 2020. The statistical analysis with Spearman test using the SPSS 17.0 program. There are 274 subjectswith non-severe and severe COVID-19 were NLR (3,44 vs 7,17), PLR (182,4 vs 254,4). The r coefficient of NLR and PLR reached 0.308 and 0.198, p-value of < 0.001.In the next phase, days 7-14, lymphocytes decrease significantly. This study found a weak correlation because neutrophilia occurred on the third-seventh day of treatment, while the assessment was performed at first day of admission with clinical symptoms on day 1-3. PLR and NLR have a weak positive correlation with the severity of COVID-19. Therefore, it cannot be utilized independently in determining the severity of COVID-19.