Correlation between myeloperoxidase levels and adverse cardiac events in patients undergoing coronary stent implantation

Abstract

Objective To investigate the correlation between myeloperoxidase(MPO)levels and adverse cardiac events in patients undergoing coronary stent implantation. Methods A total of 76 patients undergoing coronary stent implantation from January 2015 to June 2016 in the cardiac surgery department of our hospital were enrolled in this study.Serum levels of MPO, high sensitivity C-reactive protein(hs-CRP), and interleukin 6(IL-6)were detected by enzyme-linked immunosorbent assays(ELISA). After a one-year follow-up, the receiver operating characteristic(ROC)curve was used to determine the predictive value of the difference in MPO before and after the operation(ΔMPO)on the long-term prognosis of patients after coronary stent implantation.The correlations of ΔMPO with the traditional risk factors for coronary heart disease and adverse cardiac events were analyzed using multi-factor Logistic regression analysis. Results Serum levels of MPO, hs-CRP and IL-6 increased in patients after coronary stent implantation, compared with those before treatment(P<0.05). The results of ROC curve analysis showed that the area under the curve(AUC)value of serum ΔMPO was 0.786, the 95% confidence interval was 0.471~1.000 and the predictive value of serum ΔMPO for adverse cardiac events was significant(P<0.05). There was a significant correlation between ΔMPO and age, and the incidence of adverse cardiac events increased with increased ΔMPO levels.Logistic regression analysis showed that serum ΔMPO levels could preliminarily diagnose the cardiovascular risk after coronary stent implantation and independently predict the occurrence of adverse cardiac events. Conclusions MPO levels in peripheral blood are notably elevated in patients after coronary stent implantation when compared with pre-treatment levels.Serum ΔMPO levels can preliminarily diagnose adverse cardiac events after coronary stent implantation and can be used as a marker to predict adverse cardiac events. Key words: Coronary disease; Stents; Peroxidase