Correlation between motilin gene polymorphism and congenital hypertrophic pyloric stenosis

Abstract

Objective To investigate the correlation between motilin gene polymorphic loci rs2281820 [44C＞T] and congenital hypertrophic pyloric stenosis (CHPS) in Han Chinese. Methods A case-control study was performed in 29 sporadic CHPS cases who visited our clinic between July 2006 and August 2009, and 60 unrelated healthy controls of Han Chinese. Polymerase chain reaction (PCR) and DNA sequencing were applied for genotyping, with genotype and allele distribution compared between two groups.Results The frequencies of CC genotype and C allele had no statistical difference between CHPS group and controls [86.21% (25/29) vs 80.00% (48/60), 91.38% (53/58) vs 89.17% (107/120), both P＞0.05].Conclusion Polymorphism of motilin gene loci rs2281820 [44C＞T] is not correlated with occurrence of CHPS in Han Chinese Key words: Pyloric stenosis, hypertrophic; Motilin; Polymorphism, single nucleotide; Genotype; Gene frequency