Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention.

Rong Yu,Jian An,Tianliang Li,Ruigang Hou,Tong Wang,Huiyuan Han

doi:10.12669/pjms.37.3.3469

Abstract

Objective:To investigate the correlation between monocyte to high-density lipoprotein ratio (MHR) and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods:In this retrospective study, 120 ACS patients who received PCI in our hospital from September 2014 to August 2019 were selected and divided into MACE group and normal discharge (ND) group. Their clinical data were collected, and MHR values were compared. Logistic regression analysis was conducted to analyze the correlations between various factors and ACS. The correlation between MHR and Gensini score was subjected to Pearson’s analysis. Receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of MHR for MACE.Results:Hypertension degree, white cell count, Gensini score, MHR and the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), apolipoprotein A1 (ApoA1), ApoB, lipoprotein (a) [LP(a)] and uric acid (UA) in MACE group were significantly higher than those in ND group (P<0.05). HDLC, ApoA1, TC, MHR, LDLC and ApoB were independent risk factors for MACE of ACS patients after PCI (P<0.05). There was a positive correlation between MHR and Gensini score (r=0.832, P<0.05), and the optimal cutoff value of MHR for diagnosing MACE was 9.45.Conclusion:Serum MHR is positively correlated with Gensini score in ACS patients after PCI, which can be used as an independent predictor for MACE in hospital.

Highlights

Acute coronary syndrome (ACS) is characterized by acute onset, poor prognosis and high mortality rate, which seriously jeopardizes the life and health of patients.[1]
This study aimed to explore the correlation between monocyte to high-density lipoprotein ratio (MHR) and major adverse cardiovascular events (MACE) after Percutaneous coronary intervention (PCI), and to provide new predictors for high-risk ACS patients in clinical practice
Baseline clinical data: The baseline data of the two groups of patients were analyzed, and it was found that hypertension degree, white blood cell count, Gensini score, MHR and the levels of total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), apolipoprotein A1 (ApoA1), ApoB, LP(a) and uric acid (UA) in MACE group were significantly higher than those in normal discharge (ND) group, and the differences were statistically significant (P

Summary

Introduction

Acute coronary syndrome (ACS) is characterized by acute onset, poor prognosis and high mortality rate, which seriously jeopardizes the life and health of patients.[1]. Pak J Med Sci May - June 2021 Vol 37 No 3 www.pjms.org.pk 885 proven to play vital roles in the occurrence and development of ACS.[3] Inflammatory reaction markers, such as C-reactive protein, neutrophil-tolymphocyte ratio and platelet-to-lymphocytes ratio, have become independent predictors for coronary artery disease and are closely associated with the prognosis of ACS. The monocyte to high-density lipoprotein ratio (MHR), as a new indicator for inflammation, is of great significance in coronary artery-related diseases.[4] The role of MHR in ACS after PCI has never been reported. This study aimed to explore the correlation between MHR and major adverse cardiovascular events (MACE) after PCI, and to provide new predictors for high-risk ACS patients in clinical practice

Methods

Results

Conclusion