CORRELATION BETWEEN MONOCYTE CHEMOATTRACTANT PROTEIN 2 (MCP-2) SERUM LEVELS WITH TUBERCULOSIS SEVERITY IN CHEST X-RAYS

Abstract

Background and Objectives: Tuberculosis (TB) is a public health problem causing the death of children worldwide. Radiological features in children have distinctive characteristics that can be used as basis for diagnosis. The use of MCP-2 as a TB biomarker has been widely studied in adult patients but has not been used extensively in child tuberculosis. Objective: This study aims to determine the relationship between MCP-2 levels with severity of TB in children based on radiological features. Methods: Pediatric patients aged 18 years with suspected TB who had never undergone TB treatment in Saiful Anwar Hospital. The 60 participants who met the inclusion and exclusion criteria were analyzed for serum levels of MCP-2. The data is grouped into non-TB and TB variables and the latter were classified into mild, moderate and severe chest photos. Data analysis was done with normality and homogeneity test, then proceeded with correlation test (p 0,05). Result: The total participants are 60 subjects comprising of 30 TB patients; male 36 subjects; less body weight 17 subjects; TB scoring 6 27 subjects; TCM rif sensitive 16 subjects; Pulmonary TB 22 subjects; and moderate severity based on chest X-ray 18 subjects. The severity of the chest X-ray showed mild degree of MCP-2 level 167,97 pg/dl (102,3-568,62); moderate 284,49pg/dl (233,36-321,71); severe 594,12 pg/dl (439,07-692,03). Mann Whitney test results showed the MCP-2 level compared with severity of TB were significantly different between groups (P0,000) and there was a signficant correlation between MCP-2 levels and the severity of TB in children (P0,000) Conclusion: There are differences in MCP-2 levels in non-TB and TB patients, and there is a correlation between MCP-2 levels and the severity of TB in children.