Correlation between Molecular Subtypes and Clinical Features in Invasive Ductal Carcinoma of Breast

Abstract

Objective To investigate the distribution of different molecular subtypes of invasive ductal carcinoma of breast(IDC),and analyze the correlation between molecular subtypes and clinical features.Methods A total of 100 patients with IDC from January 2006 to June 2011 were classified into four different subtypes according to estrogen receptor(ER),progestogen receptor(PR) and epidermal growth factor-2(HER-2),and analyze their relation to the clinical features of IDC.Results Among all 100 cases,Luminal A subtype was the majority(65%),triple negative was the second largest group(17%),and Her-2 enriched and Luminal B type are the smallest groupes(17% and 7%,respectively).The ages of patients of IDC subtype were mainly between 40 and 59(73%).The ages of patients of Luminal A subtype were mainly between 40 and 49.The ages of the patients of the other three molecular subtypes were mainly between 50 and 59(P0.05).The distributions in different age groups had statistic significance(P0.05).There were more lymph nodes metastasis in Luminal B(71.4%) and HER-2 enriched(63.6%) groups(P0.05) than in Luminal A group(30.1%).The axillary lymph nodes metastasis rates of different molecular subtypes varied significantly(P0.05).As for histopathologic grading,Luminal A patients were mainly gradeⅠ,and most Triple Negative patients were grade Ⅲ(P0.05).The difference had statistic significance(P0.05).Conclusion The distributions of different molecular subtypes of IDC has significant difference.The molecular subtypes are related to the clinical features of IDC.