CORRELATION BETWEEN MICROALBUMINURIA AND CORRECTED QT INTERVAL PROLONGATION IN PATIENTS WITH DIABETES MELLITUS

Abstract

Background and Objectives: Diabetic cardiac autonomic neuropathy is a severe and common complication of diabetes. QTc prolongation is a predictor of Cardiac Autonomic Neuropathy (CAN), and microalbuminuria is a predictor of nephropathy. The main aim of the present study is to nd the association between prolonged QTc interval and microalbuminuria in Type 2 Diabetes Mellitus(T2DM). Methods: Sixty patients of type 2 diabetics, attending RLJH hospital in Kolar, were included in the study. We divided these patients into two groups, each with thirty patients. One group consists of patients with microalbuminuria and the other with normoalbuminuria. All these patients were tested for microalbuminuria and looked for QTc interval prolongation in ECG. A chi-square test was used to analyze t h e two sample proportions. Most of the p Results: atients were in the 50 to 70 years of age group. There is a signicant associa n between QTc prolongation with microalbuminuria, as evidenced by (66.6%, P-Value <0.0001). The male-tofemale ratio is 3.8:1, and as the duration of diabetes increases, there is an increase in the incidence of QTc interval prolongation andmicroalbuminuria. There was also a signicant association with retinopathy and neuropathy with cardiac autonomic neuropathy(CAN). Interpretation and Conclusion: There was a signicant association between CAN(QTc prolongation) and microalbuminuria. Microalbuminuria per se doesn't cause QTc prolongation, and the reason for this is not clearly understood. QTc prolongation is one of the independent cause of mortality seen in microalbuminuria patients, which is preventable. Hence the aim is to prevent and reduce the mortality in T2DM patients