Correlation between metabolic syndrome and uric acid stone composition

Abstract

Objective To study the relationship between metabolic syndromes and uric acid calculi. Methods We retrospectively analyzed medical records of 640 adult patients, who were diagnosed as renal calculi and finished the stone composition analysis. Among them, 394 cases were male and 246 were female. The average age was (50.9±12.8)years old. According to the diagnostic criteria of the MS, the patients were divided as metabolic syndrome group (metabolic syndrome group /MS group and non-metabolic syndrome group (non MS group); the MS group had a total of 238 cases including 151 males and 87 females. The average age was (54.1±11.0)years old. There were 402 cases in non MS group, including 243 males and 159 females, with an average age of (49.1±13.4)years old. We obtained corresponding metabolic indices. By comparing the differences between each group, the statistic were analyzed with SPSS. Results In the MS group, 42 cases was diagnosed with uric acid stones, and the non-MS group with 8 cases diagnose with uric acid stones. The MS included obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides. In the patients obtained, 123 had the 4 kinds of metabolic diseases at a time, and 23(18.7%) cases were diagnosed as uric acid stones. 115 patients had the 3 kinds of metabolic diseases in which 19(16.5%) cases were uric acid stones. 190 patients had 2 kinds of metabolic diseases and 5(2.6%) cases were uric acid stones. 137 patients had only one kinds of metabolic disease in which 3 were uric acid stones. The multivariate Logistic regression analysis showed that, after the correction of gender and age, obesity patients own the OR as 1.10(0.98-1.24)(P=0.018), high blood sugar had the OR as 1.72(1.19-1.92)(P=0.006), high glycerin three fat had the OR as 0.71(0.48-1.09)(P=0.032) and high HDL-C was 0.15(0.03-0.65)(P=0.01). Conclusions The metabolic syndromes including obesity, hyperglycemia and dyslipidemia obviously might influenced the formation of uric acid calculi. Key words: Metabolic syndrome; Uric acid calculi; Renal stones