Abstract
Introduction: Vitamin B12 (vitB12)deficiency causes failure of red blood cells (RBC) maturation leading to cell lysis causing excess heme production resulting in indirect hyperbilirubinemia. Purpose: We aimed toassess vitB12 serum levels in neonates with jaundice and compare these levels with that of apparently healthy neonates and detect the impact of the maternal vitB12 on both vitB12 and bilirubin of their neonates. Patients and methods: Complete blood count (CBC), C- reactive protein (CRP), and VitB12 were assessed in both groups; 60 full term neonates with jaundice (Group I) and 60 full term controls. VitB12 levels were assessed for the mothers of all included neonates. Results: VitB12 in jaundice neonates were significantly lower than that of controls. Maternal vitB12 was positively correlated with neonatal vitB12 and negatively correlated with neonatal total serum bilirubin levels (TSB). Conclusion: Low maternal vitB12 affects both vitB12 and bilirubin levels of their neonates.
Highlights
Vitamin B12deficiency causes failure of red blood cells (RBC) maturation leading Accepted: April 12, 2018 to cell lysis causing excess heme production resulting in indirect hyperbilirubinemia
Vitamin B12, Hemolysis, Patients and methods: Complete blood count (CBC), C- reactive protein (CRP), and VitB12 were Intrinsic factor assessed in both groups; 60 full term neonates with jaundice (Group I) and 60 full term controls
Maternal Vitamin B12 (vitB12) was positively correlated with neonatal vitB12 and negatively correlated with neonatal total serum bilirubin levels (TSB)
Summary
Vitamin B12 (vitB12)deficiency causes failure of red blood cells (RBC) maturation leading Accepted: April 12, 2018 to cell lysis causing excess heme production resulting in indirect hyperbilirubinemia.Published: April 14, 2018Purpose: We aimed toassess vitB12 serum levels in neonates with jaundice and compare these levels with that of apparently healthy neonates and detect the impact of the maternal vitB12 on both vitB12 and Keywords: bilirubin of their neonates.Jaundice, Vitamin B12, Hemolysis, Patients and methods: Complete blood count (CBC), C- reactive protein (CRP), and VitB12 were Intrinsic factor assessed in both groups; 60 full term neonates with jaundice (Group I) and 60 full term controls. Vitamin B12 (vitB12)deficiency causes failure of red blood cells (RBC) maturation leading Accepted: April 12, 2018 to cell lysis causing excess heme production resulting in indirect hyperbilirubinemia. VitB12 levels were assessed for the mothers of all included neonates. They were divided into 2 groups: Physiologic jaundice is caused by a combination of increased bilirubin production (secondary to accelerated destruction of erythrocytes and decreased excretory capacity secondary to low levels of ligandin in hepatocytes) and low activity of the bilirubinconjugation enzyme uridine diphospho glucuronyltransferase (UDPGT) [1]. Deficiency of VitB12 causes failure of RBC maturation leading to cell lysis which causes excess heme production resulting in indirect hyperbilirubinemia [3]. Homocysteine increases the risk of hemolysis in vitB12 deficiency and there is a high frequency of vitB12 deficiency in asymptomatic patients with homozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation, a known cause of hyperhomocysteinemia [4].
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