Abstract
Background It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study. This study is aimed at exploring the relationship between LRP1B mutations and TMB in gastric cancer. Methods Mutation frequency profiles of the genes in patients with gastric cancer in TCGA-STAD dataset were analyzed by bioinformatics analysis. The relationship among LRP1B mutations, TMB, and patient clinical features in gastric cancer was investigated by the chi-square test. The TMB prediction capacity based on LRP1B mutation status was evaluated by ROC curves. ResultsLRP1B is one of the top 10 genes with high gene mutation frequency in gastric cancer. The mutation status of LRP1B in gastric cancer patients was significantly correlated with age and TP53 and MUC16 mutation status. The result of ROC curve analysis revealed that the mutation status of LRP1B could be considered as an indicator of the degree of TMB in patients with gastric cancer. Conclusion This study presented the relationship between TMB and LRP1B mutations in gastric cancer, providing a novel perspective for gastric cancer prognosis and therapy.
Highlights
Gastric cancer is the fourth most common cancer in the world and the second primary cause of cancer-related deaths, accounting for 6.8% of all new cancer cases worldwide
The top 20 genes with mutation frequency were visualized by analyzing mutation data from 372 gastric cancer patients in TCGA-STAD dataset (Figure 1)
To investigate the role of lipoprotein receptor-related protein 1B (LRP1B) mutations in gastric cancer, we analyzed the connection between LRP1B mutations and several important clinicopathological features as well as some important biomarker genes in gastric cancer patients
Summary
Gastric cancer is the fourth most common cancer in the world and the second primary cause of cancer-related deaths, accounting for 6.8% of all new cancer cases worldwide. Numerous studies have shown that mutations in genomic integrity-related genes such as TP53 [13] and ATR [14] may lead to genomic instability and contribute to a high genomic mutation rate Mutations of these genes have been reported to be related to TMB [6, 9, 15]. It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study. The result of ROC curve analysis revealed that the mutation status of LRP1B could be considered as an indicator of the degree of TMB in patients with gastric cancer. This study presented the relationship between TMB and LRP1B mutations in gastric cancer, providing a novel perspective for gastric cancer prognosis and therapy
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