Abstract
ABSTRACT Objectives This study aimed to investigate the correlationbetween serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and poststrokemild cognitive impairment (PSMCI). Methods The patients included in the study were divided into PSMCI (68 cases)and cognitively normal (CN) (218 cases) groups and followed up for six months.Demographic and clinical data were collected. A logistic regression analysiswas performed to determine whether Lp-PLA2 is an independent risk factor forPSMCI. Spearman’s correlation analysis was used to examine the correlationbetween Lp-PLA2 levels and Montreal CognitiveAssessment (MoCA) scores. A receiver operating characteristic (ROC) curveanalysis was performed to determine the diagnostic threshold value of Lp-PLA2for PSMCI. Results Serum Lp-PLA2 levels were significantly higherin the PSMCI group than in the CN group. The logistic regression analysisshowed that Lp-PLA2 was an independent risk factor for PSMCI (OR = 1.05, 95% CI= 1.03–1.07). Spearman’s correlation analysis revealed a significantcorrelation between the Lp-PLA2 levels and MoCA scores (R= -0.49). The area under the ROC curve forLp-PLA2 was 0.849, and the threshold value for PSMCI occurrence was 236.8 ng/ml. Conclusions Elevated serum Lp-PLA2 is an independent riskfactor for PSMCI and may serve as a potential biomarker for PSMCI.
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