Abstract
Objective To compare the lipoprotein(a) (Lp-a) and lipid metabolism level in rheumatoid arthritis(RA) patients and control group (healthy subjects), and evaluate the correlation between Lp-a levels and systemic inflammation in patients with RA. Methods Blood samples from 30 RA patients with positive rheumatoid factor and 30 healthy controls were collected, with same distribution of gender and age in both groups. Lipid metabolism level such as Lp-a, triglyceride(TG), total cholesterol(TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and inflammation markers such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and C reactive protein (CRP) were detected and analyzed statistically. Results LP-a levels were higher in RA patients than that of control group(P 0.05). The TNF-α、IL-6 and CRP levels of RA patients were higher than that of control group(P<0.05), and the association between higher Lp-a level and TNF-α were confirmed (r=0.753, P<0.001). Conclusions High levels of Lp-a are often observed in RA patients, and a rising Lp-a level are associated with systematic inflammation reaction. Lp-a may be a risk factor for RA progress. Key words: Rheumatoid arthritis; Lipoprotein(a); Systematic inflammation reaction; Atherosclerosis
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
