Correlation Between Lipid Profile and Kidney Function in Ambulatory Heart Failure Patient

Sidhi Laksono Purwowiyoto,Steven Philip Surya,Budhi Setianto,Hengkie Frankie Lasanudin,Wincent Candra Diwirya

doi:10.18196/mmjkk.v1i1.9969

Abstract

Heart failure contributes to a high number of hospitalizations. Currently, the number of outpatients is more dominant than hospitalized heart failure patients. Unfortunately, a study in the outpatient setting is still limited. This study aims to evaluate the correlation between lipid profile and kidney function in ambulatory heart failure patients. This study is a single-center cross-sectional study. Data were collected from August to September 2020. Data were extracted from 62 medical records of heart failure patients with ejection fraction 45%. Exclusion criteria were life-threatening comorbidity and patient with routine hemodialysis. Data were analyzed with Pearson or Spearman correlation test. Most of the heart failure patients in our outpatient clinic are elderly (60 years old) and male (58%). The researchers found positive correlation of total cholesterol (r 0.39; p 0.001) and triglyceride (r 0.59; p 0.001) to serum creatinine. On the other hand, LDL and blood cholesterol ratio negatively correlated with serum creatinine, r - 0.31; p 0.016; and r - 0.46; p 0.001; respectively. All of this analysis was statistically significant. It concluded that lipid profiles were correlated with kidney function in heart failure patients

Highlights

Heart failure is a medical syndrome caused by alteration and structure of the heart, which contributes to less cardiac output and upraised intracardiac pressure at rest or during stress
Long-term mortality outcome confirms substantial difference of a number of the mortality heart failure patient with kidney dysfunction compared to heart failure patients with normal kidney function.[7]
This study aims to determine the correlation between lipid profile and kidney function in ambulatory heart failure patients

Summary

Introduction

Heart failure is a medical syndrome caused by alteration and structure of the heart, which contributes to less cardiac output and upraised intracardiac pressure at rest or during stress. The clinical syndrome includes orthopnea, lower limb swelling, and objective findings like prominent jugular venous pressure (JVP) and pulmonary congestion.[1] In developed countries, international studies ratify heart failure happen in 1-2% in the adult population, and it would trigger escalation up to a minimum of 10% amongst elderly.[2] In Asia-Pacific Region, including Indonesia, it is suggested a higher hospitalization rate than Western countries.[3,4]. Long-term mortality outcome confirms substantial difference of a number of the mortality heart failure patient with kidney dysfunction compared to heart failure patients with normal kidney function (estimated glomerular filtration rate/ eGFR

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