Correlation between Lipid parameters and gamma glutamyl transferase in type 2 diabetes mellitus

Abstract

Background: Serum gamma glutamyl transferase (GGT) which is a simple and reliable marker of liver fat deposition leads to hepatic insulin resistance and long term hepatic insulin resistance may lead to type 2diabetes mellitus (DM). In this context, the present study was under taken to study the serum GGT levels and its possible associations with serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and high density lipoprotein cholesterol (HDL-D) in type 2 DM. Material and methods: The study was conducted at HSK hospital, Bagalkot from Jan 2016 to Jun 2016. The diagnosis of DM was based on WHO criteria. Sixty subjects participated in each group (DM and Controls). Fasting sample was collected and fasting blood sugar (FBS), HbA1c, urea, creatinine, GGT, and lipid parameters were estimated. Data was analysed using SPSS software. Student’s t test and Pearson correlation was applied for quantitative data. Results: The serum levels of FBS, PPBS, HbA1c, creatinine, urea, TG and VLDL were raised significantly in cases compared to controls, whereas serum HDL was significantly decreased in cases compared to controls (p=0.000). There was statistically significant (p=0.001) positive correlation between the TGL and GGT. HDL-C was significantly, negatively correlated with GGT. Conclusion: There was positive correlation between GGT and TG, TC, LDL-C and VLDL-C, only TGL was significant, and there was significant negative correlation between HDL and GGT. Hence serum GGT can be used as marker of cardiovascular diseases in type 2 DM patients. Key words: Diabetes mellitus, Gamma Glutamyl transferase, Lipid profile