Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

Elena López-Ramiro

doi:10.11648/j.ajcem.20170504.18

Abstract

Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis. Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO<sub>2</sub>, cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman’s correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.

Highlights

Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis.Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD)
The results show a positive correlation with the parameters related with the degree of anemia of these patients
Important is the fact that the correlations between levels of 25(OH)D and hemoglobin, hematocrit, iron, iron saturation index, and ferritin are quite independent between them

Summary

Introduction

Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis.Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). The efficiency of vitamin D status has been classically associated with bone pathology, the discovery that almost all body tissues and cells have vitamin D receptors (VDR) and an enzyme system to synthesize 1.25(OH) Vitamin D (1.25(OH)2D) has evidenced that vitamin D carries out other functions such as inhibition of cellular proliferation, angiogenesis, and renin production, the stimulation of cellular maturation, and the regulation of immune response For this reason, low levels of vitamin D are associated with mortality, cancer, cardiovascular disease, autoimmune diseases, diabetes, psychiatric illness, and even respiratory disease in addition to the previously known effects on bone metabolism

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