Abstract
Acute myocardial ischemia simulating angina pectoris was produced in the in situ canine heart by ligation of the left coronary artery. The quantitative relationship between changes in surface and intracellular electrograms was examined by calculating the correlation coefficient of the regression line. ST segment and T wave changes were proportional to the corresponding changes in intracellular electrograms. A quantitative linear relationship was observed between changes in surface and intracellular electrograms.recorded during acute myocardial ischemia. It was determined that the value of the proportionality constant remains unchanged during different stages of myocardial ischemia. The size of the ischemic area does not cause the value of the proportionality constant to vary. This study explains many of the electrocardiographic and vectorcardiographic changes in patients with angina pectoris.
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