Abstract
The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using <i>pearson</i> test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m<sup>2</sup>. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.
Highlights
Nowadays, the prevalence of obesity in children is increasing both in developed or developing country
Obesity is linked to chronic inflammatory condition that is proven by interluekin-6 (IL-6) increment
The incidence of anemia is higher compared to those lean children, this anemic condition may relate to inflammation that is proven by increasing hepcidin level, which is known as anemia of chronic disease or anemia of inflammation
Summary
The prevalence of obesity in children is increasing both in developed or developing country. Obesity is linked to chronic inflammatory condition that is proven by interluekin-6 (IL-6) increment. The incidence of anemia is higher compared to those lean children, this anemic condition may relate to inflammation that is proven by increasing hepcidin level, which is known as anemia of chronic disease or anemia of inflammation. This condition raise question whether there will be any correlation between IL-6 and hepcidin. The problem of iron metabolism with or without anemia in obese children is quiet high, in several country, with prevalence about 26%-45% [4, 5]
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