Abstract
Insulin resistance plays a central role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors (1). In the assessment of insulin resistance, several methods have been developed. The “gold standard” hyperinsulinemic-euglycemic clamp (2) and the insulin suppression test (IST) (3) are two established methods to quantify insulin sensitivity in vivo, but neither is easily applied in large populations. Thus, it is of interest to develop simple methods to estimate insulin sensitivity that are useful for large epidemiological studies. A mathematical model derived from the so-called homeostasis model assessment (HOMA) (4) has been described as a simple and reproducible method in clinical practice. Recently, Katz et al. (5) have described a novel quantitative insulin-sensitivity check index (QUICKI) that shows a high correlation with the hyperinsulinemic-euglycemic clamp. In the present report, we studied the correlation among IST, QUICKI, and HOMA in a population of normotensive-obese (NT-OB) and hypertensive-obese (HT-OB) patients in order to determine their accuracy. We recruited 20 obese (BMI >30 kg/m2) male patients; 12 were NT-OB, and 8 were newly HT-OB and had never been treated before. None had previous history of metabolic disorders or were on medication with effects on insulin sensitivity. As the control group, 10 healthy (BMI <25 kg/m2) age- and sex-matched volunteers were included. To estimate the insulin sensitivity, we first performed an IST. This test acts by suppressing endogenous insulin secretion with a sustained infusion of somatostatin. Simultaneously, exogenous crystalline insulin is infused at a constant rate to achieve a steady state of plasma insulin (SSPI), and then the resultant steady state of plasma glucose (SSPG), in response to a constant glucose infusion is determined, as we have previously described (6). The insulin sensitivity index (ISI) was …
Highlights
A n extremely high prevalence of diabetes has been found among South Asians, especially among immigrants living in a western society [1]
The controlled beforeand-after study (CBA) study consisted of a pretest measurement of HbA1c, BMI, and lipid profile; a measurement of HbA1c and BMI immediately after the period of intensive guidance; and a second post test measurement of HbA1c, BMI, and lipid profile 1 year later
We studied the correlation among insulin suppression test (IST), quantitative insulin-sensitivity check index (QUICKI), and homeostasis model assessment (HOMA) in a population of normotensiveobese (NT-OB) and hypertensive-obese (HT-OB) patients in order to determine their accuracy
Summary
Research Group: Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. The metabolic goal of therapy in gestational diabetes (GD) is to maintain euglycemia, and when it is not achieved with diet alone, insulin therapy is added [1] Physical training has both acute and long-term effects on insulin sensitivity, insulin secretion, and glucose metabolism in both nondiabetic and diabetic subjects [2], and the benefit of training has been shown in patients with GD, where controlled training achieves euglycemia with no need for insulin treatment [3]. The clinical observation that light postprandial exercise in patients with GD was useful in decreasing blood glucose (BG) prompted this controlled crossover study, which had the aim of assessing the magnitude of its effect in women with GD. We conclude that in addition to the benefits of physical training on blood glucose control, women with GD could benefit from light postprandial exercise and potentially avoid or delay insulin therapy. From the Endocrinology Service, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
