Abstract
Cytokines play an important role in regulating the immune response in the elderly population, and various studies indicate an inability to control systemic inflammation in the elderly, which may be a sign of ‘unsuccessful aging’. Thus, the evaluation of inflammatory cytokine profile in a healthy elderly population is a prerequisite for assessing the risk of developing the disease. The aim of the present study was to evaluate the level of cytokines - IL-6 and IL-18 in the healthy elderly population and to reveal their correlation with anthropological parameters. The results of our study shown that IL-18 levels were statistically significantly correlated with height in men and systolic blood pressure in women. IL-18 levels in the general population are reliably and strongly associated with IL-6 (r = 0.475; p = 0.001). Thus, based on our findings, evaluation of IL-6 and IL-18 concentrations can be used as biomarkers of “inflamaging”.
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