Correlation between Imaging Features and Pathological Stages of Primary Lung Tumors Based on Nanocontrast Agents.

Qian Xu,Yuliang Liu,Jin Li,Cunhua Mao

doi:10.1155/2021/2343299

Abstract

As one of the conventional methods of lung cancer detection, computed tomography (CT) usually requires the use of contrast agents to enhance the imaging effect. Conventional iodine contrast agents have poor signal-to-noise ratio and are prone to adverse reactions. It is necessary to find more effective and safe contrast agents for CT scans. The gold nanoparticles with secondary electron effect and photoelectric absorption effect can prolong the display time of the patient's blood circulation after being injected into the patient's body, which makes the nanocontrast agent a research hotspot in the field of CT imaging. In this study, ultrasmall gold nanoclusters with a diameter of about 5 nm were used as the contrast agent in CT scans. It was found that CT scans based on nanocontrast agents can obtain high-quality lung cancer imaging images, and the patient has no obvious adverse reactions. When observing the CT image, it was found that the stage of lung cancer patients can be clearly distinguished through the CT scan image. When analyzing the consistency of CT imaging and pathological classification, the Kappa value was 0.810, indicating that the two have a high degree of consistency. Therefore, this study believes that the imaging characteristics of primary lung tumors based on nanocontrast agents are highly correlated with their pathological types.

Highlights

Lung cancer is a malignant tumor that poses a great threat to human life and health
An ultrasmall gold nanocluster contrast agent was injected into the patient before the computed tomography (CT) scan (the transmission electron microscopy image and particle size distribution of the gold nanocluster are shown in Figures 3(a) and 3(b)) to extend the photography time and enhance the imaging clarity
By analyzing the imaging characteristics of lung cancer patients at different stages, we found that the lungs of patients with lung cancer can see sheet consolidation, ground glass shadows, and burrs, with clear and irregular boundaries

Summary

Introduction

Lung cancer is a malignant tumor that poses a great threat to human life and health. Its morbidity and mortality rate ranks first among malignant tumors in the world, and the morbidity and mortality rates are still on the rise [1]. A number of studies have shown that factors such as air pollution, smoking, diet, occupational carcinogens, and genetics can increase the risk of lung cancer [3,4,5]. This may be the main reason why the incidence of lung cancer has increased year by year as air pollution has increased and the number of smokers has increased. In the early stages of lung cancer, patients often experience symptoms such as irritating cough, increased sputum volume, and loss of appetite [6]. It may cause cancer cells to metastasize to the liver, kidneys, and bones, causing systemic malignancy and directly endangering the lives of patients

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Discussion

Conclusion