Correlation between hyperuricemia and microvascular complications in type 2 diabetic patients

Abstract

Objective To assess the association between hyperuricemia and microvascular complications in type 2 diabetic (T2D) patients. Methods We recruited 610 patients with T2D. Based on the level of blood uric acid, the patients were divided into a normal uric acid (NUA) group and a hyperuricemia (HUA) group. The general conditions, relevant hematology indicators, and complications were collected. Results Compared with the NUA group, the HUA group had a higher incidence in men (68.7%, P=0.000), longer duration of diabetes (P=0.033), and higher values of creatinine (Cr) (P=0.000), triglyceride (TG) (P=0.000), and low density lipoprotein cholesterol (LDL-C) (P=0.012). In addition, compared with the NUA group, the HUA group had a higher presence of drinking (P=0.012), hypertension (P = 0.000), and microvascular complications (P=0.008). The results of multivariate logistic regression analysis showed that HUA was associated with the increased risk of microvascular complications (OR=1.639, 95% CI 1.031-2.611; P=0.037), sex (OR=2.702, 95% CI 1.491-4.895; P=0.001), Cr (OR=1.050, 95% CI 1.038-1.063; P=0.000), TG (OR=1.154, 95% CI 1.043-1.277; P=0.005), and LDL-C (OR=1.281, 95% CI 1.025-1.600; P=0.029) in T2D. Conclusion HUA is associated with an increased risk of the development of microvascular complications in T2D patients. Key words: Type 2 diabetes mellitus; Blood uric acid; Microvascular complication; Risk factors