Correlation between HS-troponin I level and Brixia score in COVID-19 patients with diabetes mellitus at ICU of Dr. Moewardi Hospital, Indonesia

Abstract

COVID-19 can cause disturbances in insulin production and worsen the clinical condition of patients with comorbid diabetes mellitus. In patients with diabetes mellitus, one of the complications is heart disease. Therefore, a study was conducted to determine the relationship between hs-Troponin I levels, which is a biomarker of heart disease, with the severity of COVID-19 patients as measured by the Brixia score in COVID-19 patients with comorbid diabetes mellitus in the ICU (Intensive Care Unit) of Dr. Moewardi Hospital, Surakarta. The study was conducted with a cross-sectional approach, the sample was COVID-19 patients with comorbid diabetes mellitus in the ICU, chosen by purposive sampling method. The dependent variable of this study was the Brixia score, and hs-Troponin I would be the independent variable. Data were analyzed by contingency coefficient test with p<0.05 indicating statistical correlation. 44 patients hospitalized in ICU for COVID-19 were enrolled. The mean age was 61±8 years old. 27% of patients had normal hs-Troponin I levels, and 73% had elevated hs-Troponin I levels. 11% of patients had a low Brixia score, 43% had a moderate score, and 45% had a high score. Data were analyzed, and the result is the value of X2 count=2.804 < X2 table=5.991 which means that there is no relationship between variables. The values of p=0,246 (p>0,05) and r=0,245 showed that there is no significant relationship between hs-Troponin I and Brixia score. Hs-Troponin I level is negatively correlated to Brixia score in COVID-19 patients with diabetes mellitus.