Correlation between HS-CRP in Serum with Neurological Deficit Measured by Nihss in Acute Ischemic Stroke

Abstract

Background: CRP can increase the regulation of adhesion receptors on endothelial cells which can lead toinfiltration of neutrophil and monocyte cells to endothelial cells. This causes endothelial cell damage andblood brain barrier dysfunction eventually leading to brain cell death. This brain cell death will result inimpaired brain function and affect the severity of the stroke. The problem that arises is whether there is acorrelation between CRP levels in serum and the severity of acute ischemic stroke as measured by NIHSS.Method: Sixty patients with acute thrombotic stroke who were treated at the neurology ward of Dr.SoetomoGeneral Hospital (a Teaching Hospital of Faculty of Medicine, Universitas Airlangga) during June-September2019 had serum levels of CRP measured with sandwich ELISA method using high sensitivity CRP (hs-CRP)and neurological deficit was assessed using the NIHSS.Result: Mean age of subjects was 57,45±8,89 years. The study subjects consisted of 37 male and 23 female.The median serum levels of hs-CRP is 0,4 mg/dL with a range of 0,1-15,1 mg/dL. Median NIHSS is 5 witha range of 2-15. There is a positive correlation with moderate correlation strength between serum levels ofhs-CRP and the NIHSS value in patients with acute thrombotic stroke and statistically significant (p=0.000,r=0.454).Conclusion: There is a moderate positive correlation between serum levels of hs-CRP and neurologicaldeficit measured by NIHSS.