Correlation between Hp Infection with Clinicopathological Features, Tumor Markers, Oncogene Expression in Patients with Gastric Cancer

Abstract

Objective: To study the correlation between Helicobacter pylori (Hp) infection with clinicopathological features, tumor markers, oncogene expression in patients with gastric cancer. Methods: 180 gastric cancer patients who underwent surgical resection in our hospital from February 2019 to March 2021 were selected. The clinicopathological characteristics of the patients were collected. The content of tumor markers was measured after serum collection. The HP infection and oncogene expression were measured after the collection of gastric cancer lesions and adjacent lesions. Results: The HP infection rate in 180 cases of gastric cancer was 56.67%; the HP infection rate in TNM stage III and TNM stage II was significantly higher than that in TNM stage I and the HP infection rate in TNM stage III was significantly higher than that in TNM stage II; the HP infection rate in poorly differentiated gastric cancer was significantly higher than that in moderately differentiated gastric cancer; the HP infection rate in gastric cancer tissues with depth of T3+T4 was significantly higher than that of T1+T2. The levels of serum CEA, CA19-9 and VEGF in patients with HP-positive gastric cancer tissues were significantly higher than those in patients with HP-negative gastric cancer tissues, the level of PGR was significantly lower than those in patients with HP-negative gastric cancer tissues;  the mRNA expression of c-myc, c-Met and Bmi-1 in HP-positive gastric cancer tissues were significantly higher than those in HP-negative gastric cancer tissues; the mRNA expression of GKN1 and p16 were significantly lower than those in HP-negative gastric cancer tissues. Conclusion: Hp infection in patients with gastric cancer correlates with the changes of clinicopathological features, the increase of tumor markers and abnormal expression of oncogene.