Correlation between Histopathological Diagnosis and Real-Time Tissue Elastography Scores.

Abstract

Abstract Background“Hardness” is important characteristics of carcinoma. Recent invention of Real-time Tissue Elastography (EG) has made scaling the hardness possible. At 31st SABCS, we reported that B-mode ultrasound(US)+mammography(MMG)+EG demonstrated high sensitivity even for the malignancy of the mass-forming lesions of 1.1 cm or smaller in diameter. This results suggested that possibility of a mass-forming lesion being malignant is ignorable low when it is judged as “not malignant” by this combined method. In this study, we verified correlation between EG score and histopathological diagnosis.Method416 patients with mass-forming and non-mass-forming breast lesions (118 malignant, 298 benign) whose tissues were diagnosed by histopathologically from October 2007 to March 2009 were studied. The hardness was scored on a scale 1 to 5 on Tsukuba elasticity scoring system.ResultsIn mass-forming breast lesions, the mean overall score of malignant diseases was 4.1 (invasive carcinoma 4.3, noninvasive carcinoma 3.5), and the mean overall score of benign diseases was 2.4, and thus scores of malignant diseases were significantly high (< 0.0001). On the other hand, in non-mass-forming breast lesions, the mean overall score of malignant diseases was 2.3 (invasive carcinoma 2.5, noninvasive carcinoma 2.4), and the mean overall score of benign diseases was 2.0, and thus no differences were seen between them. Furthermore, for examination by mass-forming lesions combined with non-mass-forming lesions the mean score of noninvasive carcinomas was 2.5.ConclusionIt was found that in mass-forming lesions, high scores suggest invasive carcinoma and low scores suggest benign diseases. However, as in non-mass-forming lesions, both invasive and noninvasive carcinomas almost show no high EG scores, it appeared necessary to look into invasive examinations such as biopsy for the diagnosis of non-mass-forming lesions. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5026.