Abstract
SummaryRecurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according to the population studied.Aimto typify class I and class II HLA molecules and to assess how frequent these molecules are present in the Brazilian population with Recurrent Aphthous Stomatitis, compared to healthy controls.Materials and MethodsIn this prospective, cross-sectional and investigative study, thirty one patients with diagnostic hypothesis of recurrent aphthous stomatitis were seen from February of 2004 to May of 2006. We obtained the DNA from those patients who matched the inclusion criteria and typified their HLA by PCR.ResultsIn those patients with Recurrent Minor Aphthous Stomatitis we found statistically significant occurrences of HLA-A33 and HLA-B35.ConclusionHLA-A33 and HLA-B35 may be associated with recurrent minor aphthous stomatitis in the Brazilian's population.
Highlights
Recurrent Aphthoid Stomatitis (RAS) is a common disease that causes the appearance of recurrent aphtha in the oral mucosa
RAS is currently defined as a disease characterized by aphtha lesions in the oral mucosa, in a recurrent fashion, for a minimum period of one year, and its onset is usually in childhood or adolescence[2], without evidences of associated systemic diseases
Regarding the frequency type of Class I an II HLA antigens in the study group, Table 2 shows the frequency of each patient
Summary
Recurrent Aphthoid Stomatitis (RAS) is a common disease that causes the appearance of recurrent aphtha in the oral mucosa. Its incidence is of about 20% in the world population. Many studies dedicated to unveiling its causes, it still is very controversial regarding etiology[1]. RAS is currently defined as a disease characterized by aphtha lesions in the oral mucosa, in a recurrent fashion (every fortnight or monthly), for a minimum period of one year, and its onset is usually in childhood or adolescence[2], without evidences of associated systemic diseases. Some authors state that the incidence of RAS is greater in the second decade of life[3,4]
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