Correlation between hepatic venous pressure gradient and clinic features in patients with liver cirrhosis

Abstract

Objective To investigate the correlation between hepatic venous pressure gradient (HVPG) and clinic features, laboratory results in patients with liver cirrhosis. Methods From December 2012 to April 2014, patients with liver cirrhosis who received HVPG examination were enrolled. The clinical data of the patients were collected, which included etiology of cirrhosis, albumin, creatine, total bilirubin, international normal ratio (INR), history of ascite and bleeding, degree of gastroesophageal varices under endoscopy, the scores of Child-Pugh and model for end-stage liver disease (MELD). Single factor and multiple factor linear regression method were performed to analyze the correlation between these indexes and HVPG. Results A total of 63 patients met the inclusion criteria. Among them, six patients had abnormal shunt in liver venous and HVPG examination failed. The HVPG of the left 57 patients was 9.50 to 33.20 mmHg (1 mmHg=0.133 kPa), mean (16.38±5.64) mmHg.The results of single factor regression analysis indicated that there were certain relevance between the level of albumin (r2=0.145, P=0.002), Child-Pugh score (r2=0.069, P=0.048) and HVPG. Multiple factor analysis indicated that there were certain relevance between albumin (B=-4.920, t=-3.521, P=0.001), total bilirubin (B=4.066, t=2.206, P=0.032) and HVPG, and there were no relevance between the other indexes and HVPG. Conclusion Only albumin and total bilirubin level in patients with liver cirrhosis are correlated with the level of HVPG. Key words: Hepatic venous pressure gradient; Liver cirrhosis; Child-Pugh score; MELD score