Abstract
Abstract: As many as 7 – 12% of the world's population has chronic kidney disease (CKD). CKD patients can experience various complications, one of which is anemia. Anemia can cause a variety of cardiovascular complications in CKD patients. Enforcement of the diagnosis of anemia and its type is carried out by laboratory examination, among others by examination of reticulocytes-hemoglobin (ret-he) and iron status such as serum ferritin. Examination of these parameters can help in planning the right treatment for CKD patients who have anemia. The purpose of this study was to determine the relationship of Ret-he with ferritin levels in CKD patients undergoing hemodialysis at PKU Bantul Hospital. This study used cross-sectional method. The data source used was secondary data obtained from medical records and the Indonesian Renal Registry (IRR). Sampling research used consecutive sampling method. The analysis used univariate analysis which was frequency distribution table, and bivariate analysis. Univariate analysis obtained that average levels of ret-he from 50 subjects was 28.87 ± 3.75 pg and median serum ferritin levels were 118,1 (9,76 – 1615) mL. Bivariate analysis with pearson correlation test found a significant correlation between serum ret-he and ferritin levels (r = 0.498, p = 0.000).There was a significant correlation between he-ret levels and serum ferritin levels Keywords: chronic kidney disease, anemia, reticulocytes-hemoglobin, serum ferritin.
Highlights
Chronic kidney disease (CKD) is still a public health problem, especially the people of Indonesia with a high incidence rate, as well as high morbidity and mortality rates
Data in the United States shows that the most frequent causes of chronic kidney disease (CKD) are type 2 diabetes mellitus (30%-50%), hypertension (27.2%), and primary glomerulonephritis (8.2%), while the most common causes of CKD in Indonesia according to the Ministry of Health are diabetes mellitus, hypertension, chronic glomerulonephritis, obesity, and the rest are unknown.[3,4]
This is evident from the report of the Indonesian Renal Registry (IRR) program by the Indonesian Nephrology Association (Pernefri) on data related to dialysis, kidney transplantation, as well as epidemiological data on kidney disease and hypertension throughout Indonesia
Summary
Chronic kidney disease (CKD) is still a public health problem, especially the people of Indonesia with a high incidence rate, as well as high morbidity and mortality rates. Chronic kidney disease includes a spectrum of various pathophysiological processes associated with renal abnormalities and a progressive decrease in the glomerular filtration rate (GFR), including GFR < 60 mL/min/1.73 m2, albuminuria, imaging-proven renal structural abnormalities, abnormalities renal tubules, and a history of kidney transplantation.1.2. According to the 2013 Riskesdas, the prevalence of CKD is directly proportional to the increasing number of elderly people and the incidence of diabetes mellitus and hypertension.[3] This is evident from the report of the Indonesian Renal Registry (IRR) program by the Indonesian Nephrology Association (Pernefri) on data related to dialysis, kidney transplantation, as well as epidemiological data on kidney disease and hypertension throughout Indonesia. In 2017, the most CKD patients were aged 55-64 years with a percentage of 30.45%, followed by CKD patients aged 45-54 years with a percentage of 29.57%, while the rest were aged less from 45 years by 23.31%, and CKD patients aged over 65 years by 16.14%.5
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