Correlation between hemoglobin glycation index and carotid intima-media thickness in patients with type 2 diabetes mellitus

Abstract

Objective To study the correlation between hemoglobin glycation index (HGI) and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 462 patients with T2DM hospitalized in the Clinical Medical College of Yangzhou University from January 2015 to June 2018 were selected and their clinical data were collected. According to HGI value, patients were divided into low HGI group, medium HGI group and high HGI group by tri-quartile method. The differences of each index among the three groups were compared and the correlations between HGI and CIMT were analyzed. Results There was no significant difference in these indexes among the three groups, including sex, age, course of diabetes, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, white blood cell count, high density lipoprotein cholesterol and serum uric acid (P>0.05). However, the levels of glycation hemoglobin, postprandial 2-hour plasma glucose, fasting C-peptide, total cholesterol, triglyceride, low density lipoprotein cholesterol, CIMT and number of patients with incrassated CIMT were significantly different among the three groups (P<0.05). Logistic regression analysis showed that elevated HGI was an independent risk factor for increased CIMT (OR=1.158, 95% CI: 1.022- 1.312). Conclusions HGI has important reference value in predicting the occurrence of cardiovascular disease in patients with T2DM. Key words: Type 2 diabetes mellitus; Glycosylated hemoglobin; Hemoglobin glycation index; Carotid intima-media thickness