Correlation between Helicobacter Pylori Infection with Gastroesophageal Reflux Disease Degree

Abstract

Background: Gastroesophageal reflux disease (GERD) is a pathological condition as a result of gastric contents reflux into the esophagus. Acid reflux is the major irritant for the esophagus in the development and progression of GERD. A number of theories have developed regarding the correlation of gastric acid secretion and the development of GERD, one of which has attracted attention and controversy is the effect of Helicobacter pylori (H. Pylori) infection on acid secretion. This study aims to look at the correlation of the GERD degree with H Pylori infection. Methods: This was an observational study with a cross-sectional approach in GERD patients who were diagnosed based on endoscopic examination at the Gastro Center of Wahidin Sudirohusodo Hospital and histopathology examination was performed to determine the presence of H. pylori infection from July 2017 to December 2018. Statistical analysis was performed by descriptive and frequency distribution with Chi Square test statistics using SPSS 25 Results: There were 151 subjects, 85 male subjects (56.3%) and 66 female subjects (43.7%), 20 subjects (13.2%) of whom had H. pylori infection. In this study the GERD degree was more mild with H. pylori infection than with negative H. pylori infection, but the correlation was not statistically significant. Conclusion: The degree of GERD in H. pylori infection is more mild though there is no significant correlation.