Abstract
BackgroundNonalcoholic fatty liver disease (NAFLD) is one of the most important liver diseases. High-density lipoprotein (HDL) has anti-atherogenic properties and its reduction can be associated with fatty liver. Serum ferritin levels are usually elevated in patients with NAFLD. This study aimed to evaluate the correlation between HDL subtypes and serum ferritin levels with evidence of NAFLD in liver histology of organ donors.Methods One hundred organ donor patients who were eligible for the study were included in the study and ferritin; HDL2 and HDL3 were measured in blood samples. Donated liver tissue biopsy specimens were evaluated for fatty liver and NAFLD activity score (NAS). In addition, AST and ALT were measured in recipients 24 h after transplant. All data abstracted and analyzed statistically.ResultsSerum HDL2 levels and HDL2/HDL3 ratio in patients with NAS > 1 were significantly lower (P < 0.05). Serum levels of HDL3 and ferritin were not significantly associated with NAS >1 (P > 0.05). In addition, serum ferritin > 1000 ng/ml in organ donors associated with increased AST and ALT levels 24 h after transplantation in the liver organ recipient.ConclusionsLower HDL2 values and HDL2/HDL3 ratio were associated with increased NAFLD activity score, but HDL3 and ferritin did not show such a relationship. In addition, higher levels of ferritin in organ donors may be associated with increased AST and ALT 24 h after liver transplantation in the organ recipient.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is a form of hepatic steatosis in the absence of other causes of fat accumulation in the liver which is one of the most important liver diseases
Patients with NAFLD may have mild to moderate increases in liver enzymes (AST and Alanine transaminase (ALT)), normal aminotransferases do not rule out NAFLD
The results showed that ferritin levels greater than 1000 ng/ml in organ donors were associated with an increase in Aspartate aminotransferase (AST) and ALT levels 24 h after transplantation in the recipients
Summary
Non-alcoholic fatty liver disease (NAFLD) is a form of hepatic steatosis in the absence of other causes of fat accumulation in the liver (such as heavy alcohol consumption) which is one of the most important liver diseases. Patients with NAFLD have hepatic steatosis with or without inflammation and fibrosis [1]. The severity of elevated aminotransferases does not predict liver inflammation or fibrosis, and normal aminotransferases levels are not a sign of normal liver histology [2,3,4]. Fatty liver is associated with atherosclerosis and related diseases. Low HDL levels are associated with an increased risk of atherosclerosis [2, 4]. High-density lipoprotein (HDL) has anti-atherogenic properties and its reduction can be associated with fatty liver. Serum ferritin levels are usually elevated in patients with NAFLD. This study aimed to evaluate the correlation between HDL subtypes and serum ferritin levels with evidence of NAFLD in liver histology of organ donors
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