Correlation between HCV genotype and anti-HCV antibody level in hepatitis C patients

Abstract

Objective To investigate the relationship between anti-HCV antibody level and hepatitis C virus genotype in the patients. Methods Total of 603 anti-HCV positive serum samples were collected during 2013 to 2014 by retrospective research method. HCV RNA were detected in anti-HCV positive samples by repeat test and the genotype were detected in HCV RNA positive samples.The distribution of anti-HCV level in different hepatitis C genotype patients was analyzed and the body's response to viral antibodies and viral genotype correlation with anti-HCV concentration interquartile range was explored. Rates among genotype groups were compared using chi-square test. Results Totally 412 of 603(68.33%) samples were anti-HCV positive by double reagent screening. 174(42.3%) samples were detected as HCV RNA positive. The distributions of different anti-HCV level in different genotype patients were 1a(n=8)1/8, 1/8, 4/8, 2/8; 1b(n=112)25.9%(29/112), 17.0%(19/112), 25.9%(29/112), 31.3%(35/112); 2a(n=14)3/14, 4/14, 5/14, 2/14; 3a(n=11)3/11, 6/11, 2/11, 0/11; 3b(n=16)4/16, 11/16, 1/16, 0/16; 6a(n=8)2/8, 2/8, 1/8, 3/8 with anti-HCV concentration interquartile range respectively. The anti-HCV concentration distribution was different in patients with different HCV genotypes. The anti-HCV concentration distribution in patients of 1b, 2a and 6a genotypes were evently, while anti-HCV level was relatively high in 1a (13.65) and relatively low in 3b (8.77). There were differences in different genotypes of antibody concentrations (χ2=35.2, P<0.05). Conclusions There was correlation between anti-HCV level and HCV genotype. Because there were fewer cases in some genotypes, it was necessary to investigate more samples to corfirm the above results.(Chin J Lab Med, 2016, 39: 95-98) Key words: Hepacivirus; Genotype; Hepatitis C Antibodies; RNA, Viral