Abstract
ObjectivesAnimal studies have shown that glutamate receptor ionotropic kainate 2 (GRIK2) gene knockout mice are more impulsive and aggressive. This study aims to verify whether the rs6922753 and rs2227283 polymorphisms of the GRIK2 gene are associated with both aggressive behavior and bipolar mania in the Chinese Han population.MethodsPolymerase chain reaction (PCR) was applied in the genotype rs6922753 and rs2227283 polymorphisms of the GRIK2 gene in 201 bipolar manic patients with aggressive behaviors, 198 bipolar manic patients without aggressive behaviors, and 132 healthy controls. The Modified Overt Aggression Scale (MOAS) was used to evaluate aggressive behavior in patients with bipolar mania.ResultsNo correlation was found between aggressive behavior and the rs6922753 polymorphism in the three groups. The A/A genotype and A allele of the rs2227283 polymorphism were found significantly more frequently in patients with aggressive behavior than in healthy controls (p = .004 and p = .013, respectively) and in patients with nonaggressive behavior (p = .002 and p = .018, respectively). The A/A genotype and A allele were associated with an increased risk of aggressive behavior.ConclusionThis study suggests that the rs2227283 polymorphism of the GRIK2 gene is related to aggressive behaviors in bipolar manic patients and that the A/A genotype and A allele may increase the risk of the aggressive behavior in bipolar manic patients.
Highlights
Bipolar disorder (BD) is a chronic mental disorder characterized by the alternation of mania and depression, with a prevalence rate of approximately 0.8% worldwide (Ferrari et al, 2016)
Another study found that the rs6922753 and rs2227283 polymorphisms of the glutamate receptor ionotropic kainate 2 (GRIK2) gene in schizophrenia were significantly related to aggressive behavior in the Chinese Han population (Wang et al, 2006)
Another study reported that the rs2227283 polymorphism of the GRIK2 gene in schizophrenia was significantly related to aggressive behavior, and the A allele was a risk factor for ag‐ gressive behavior in the Chinese Han population (Wang et al, 2006)
Summary
Bipolar disorder (BD) is a chronic mental disorder characterized by the alternation of mania and depression, with a prevalence rate of approximately 0.8% worldwide (Ferrari et al, 2016). Aggressive behavior is a common symptom in psychiatry, and it can be classi‐ fied into three categories among the patients who suffer from men‐ tal disorders in a broad sense: impulsive, segmental, and psychotic aggressive behavior (Hu, 2017). A large proportion of aggression in patients with bipolar disorder belongs to impulsive aggression since. Bipolar disorder patients have higher aggression scores than healthy controls (Ballester et al, 2012; Chou et al, 2013). Aggressive be‐ havior is common among bipolar disorder, during manic episodes (Belete et al, 2016). If the risk of aggressive behaviors with bipolar disorder is assessed and identified early, the risk of injury to patients and medical staff will be greatly reduced
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