Abstract
Background: Glioma is the most common primary brain tumor, originally arise from glial cells. In Indonesia, other than surgery, other therapy has not yet been developed. Thus, glioma patients showed high therapy resistancy and recurrency. Isositrat dehidrogenase (IDH) catalyzes decarboxylation of isositrat to alfa-ketoglutarat. IDH1 mutations were found in 70-80% glioma grade II, III and secondary glioblastoma multiforme (GBM). It is related to better prognosis and eligibility of IDH1 inhibitor administration.
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