Abstract
Abstract Objective Treatment of gastrointestinal stromal tumors(GISTs) is facing a bottleneck. Ghrelin is mainly produced by stomach fundus, and can promote proliferation of malignant tumors. Ghrelin may provide new ideas for GISTs diagnosis and treatment. 1) whether Ghrelin can be useful for GISTs diagnosis and prognosis. 2) Ghrelin mechanism GISTs growth regulation. Method 1) Collect serum of normal people, GISTs and patients with digestive tract malignant tumor and determine the level of ghrelin in serum. GISTs and paracancerous normal tissues were collected and ghrelin and its receptor were measured. We correlated ghrelin with clinicopathological data, analyzed the correlation between ghrelin and GISTs and its role in nutritional risk assessment. 2) The mechanism of ghrelin regulating the growth of GISTs was preliminarily explored by cell slicing, cell proliferation assay and Western blotting. Result 1) Serum Ghrelin can be used as a reference index for the existence of GISTs, but no specificity. Prognosis can not be predicted by serum Ghrelin. 2) Ghrelin of GISTs can be used as a reference index for GISTs malignant degree and recurrence risk. 3) GISTs secrete Ghrelin through autocrine and paracrine. 4) Ghrelin and its receptor antagonists can induce ghrelin receptor expression. 5) Ghrelin participates in the regulation of GISTs growth through multiple pathways. 6) Ghrelin can be used as a useful reference index for judging nutritional risk. Conclusion Ghrelin participates in the growth regulation of GISTs and has certain reference significance for judging the malignant degree, recurrence risk and perioperative nutritional risk of patients with gastrointestinal malignancies.
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