Abstract
To investigate the relation between genotoxicity and interleukin-6 in rats exposed to cigarette smoke. An experimental study. Army Medical College, Rawalpindi and Armed Forces Institute of Pathology, Rawalpindi, in 2016. Seventy healthy Sprague Dawley rats were placed in smoke chambers at animal house of National Institute of Health, Islamabad. Cigarette smoke was given to them for 3 months. Genotoxicity was assessed by CytokinesisBlock Micronucleus (CBMN) assay. Enzyme linked immunosorbent assay (ELISA) kit was used to determine Interleukin-6 in study samples. Pearson correlation was used to find the correlation between genotoxicity and IL-6. The mean IL-6 and micronuclei frequency was 49.48 ±19.69 ng/L and 6.77 ±0.73, respectively. Weak positive association was found between micronuclei frequency and IL-6 in smoke exposed rats (r=0.266, N=70, p=0.026). Genotoxicity and inflammation are associated in smokers. The present study concluded that smoke exposure elicited a proinflammatory profile, which might have promoted DNA damage in smokers.
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