Abstract
Indomethacin microspheres were prepared by an emulsion solvent evaporation method. Ethylcellulose was used as the matrix material at 1:1 drug/polymer ratio. The prepared microspheres was tested for drug content, dissolution characteristics, anti-inflammatory effect in rats and for their possible gastric effect in rabbits .A controlled release pattern of the medicament was found to be existed from the prepared microspheres. The prepared microspheres gave an anti-inflammatory effect in rats as that produced by the intact medicament. Histological examination of rabbit's stomach proved the superiority of the tested microsphere over the intact drug.
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