Correlation between G894T polymorphism eNOS gene and development of periodontal pathology in patients with bronchialcardiac diseases

Abstract

Objective — to establish possible connection between eNOS gene G894T polymorphism with a risk of pathology developing in the periodontal patients against the background of COPD comorbid with CHD.Materials and methods. The examinations involved 171 patients (115 patients with COPD in combination with СHD, 28 patients with CHD, 27 COPD patients) and 20 somatically healthy patients. The methods of examination included clinical dental examination and polymerase chain reaction.Results and discussion. It has been established that carriers of G894T and T894T genotypes (рχ2 = 0.0001) prevailed in patients with periodontitis. The heterozygous genotype G894T was found in 75.9 % of the patients with periodontitis and 36.8 % patients of the control group without periodontitis. The homozygous genotype T894T was found in 12.7 % of patients and in 5.3 % of the control group. The results showed that patients with comorbid pathology carrying the GG-genotype have higher risk of developing atrophic changes in the periodontal tissues, whereas the TT genotype is responsible for the development of inflammatory processes in the same category of subjects.Conclusions. The presence of eNOS gene G894T polymorphism can be significant in the development of periodontal tissues pathology in patients with cardiopulmonary pathology. This data can be highly significant as prognostic factor in the risk group formation.