Abstract
Epilepsy, if not treated properly, can develop into refractory epilepsy or drug-resistant epilepsy. This type of epilepsy does not respond perfectly to the anti-epileptic drugs given. Drug-resistant epilepsy causes ischemia in neuron cells in the brain. Drug resistant epilepsy can cause impaired cognitive function, especially in children who are in the golden age. Epilepsy prevalence from various studies ranged from 1.5 to 31/1000 population. Epilepsy cases in Indonesia are predicted to range from 0.7 to 1% of the population in Indonesia or range from 1.5 to 2 million people. To determine correlation between the frequency of seizures with the level of cognitive development in children with drug resistant epilepsy. A cross sectional correlation study was carried out in 41 children with drug resistant epilepsy to determine cognitive values in drug resistant epileptic children. The sample was chosen from an affordable population by non-random sampling or consecutive sampling. The research hypothesis is there is a level of cognitive development in children aged 6 to 68 months with drug resistant epilepsy. Calculation of research subjects used the formula for correlative research. Data analysis was performed by Saphiro-Wilk data normality test, correlation analysis used Coefficient Lambda. Results were significant if the value of p<0.05. The results of this study found female subject 26 (63.4%). There were 16 subjects (39%) well nourished. diagnosis age of epilepsy<1 year 15 (37%). Number of seizure periods < 10 times 12 (29%). The number of anti-seizure medication were 2 drugs 27 subject (65%). Abnormal 1 EEG results were 8 subjects (19.5%). The Mullen Scale test results are below average 38 subject (97.2%). Strong correlation of seizure frequency ≥ 10 times was statistically significant to the level of cognitive development in children with epilepsy with r 0.783 with a p value was 0.00. Frequency of seizure 43.3% influenced cognitive development level. Conclusion, the frequency of seizures has a positive strong correlation to the level of cognitive development.
Highlights
Drug resistant epilepsy defined as a failure of adequate trials of two tolerated and appropriately chosen antiepileptic drugs (AED) schedules to achieve seizure freedom
Refractory epilepsy or drug resistant epilepsy is often caused by resistance to antiepileptic drugs
The inclusion criteria in this study consisted of children from 6 until 68 months with drug resistant epilepsy, still got antiepileptic drugs, parent agreed to participate in this study
Summary
Drug resistant epilepsy defined as a failure of adequate trials of two tolerated and appropriately chosen antiepileptic drugs (AED) schedules (whether as monotherapies or in combination) to achieve seizure freedom. Refractory epilepsy or drug resistant epilepsy is often caused by resistance to antiepileptic drugs. Epileptic patients who do not successfully controlled by antiepileptic drugs can be considered experienced drug resistant epilepsy. During 0 to 5 years age, children's brain going to have formation of nerve cells. When the child suffered epilepsy during the golden age will the formation of the brain's nerve cells will disturb. Disruption of the formation of nerve cells that causes a decrease in cognitive function in children who have an impact on the quantity and the quality of life of the child itself [2]
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