Correlation between Framingham risk score and degree of asymptomatic intracranial artery stenosis on stroke prone person

Abstract

Intracranial artery stenosis is the most frequent cause of ischemic stroke. Yet there is no recommendation for population-based screening with the goal of primary stroke prevention strategies. Framingham risk score D’Agostino’s modification has been shown as highly accurate screening to assess the risk of intracranial artery stenosis that lead to stroke. The aims of study to determine the correlation between Framingham risk score and degree of asymptomatic intracranial artery stenosis among stroke prone person. In the study, 32 patients were included. Intracranial stenosis was assessed by transcranial Doppler (TCD). Stenosis defined if the mean flow velocity (MFV) value was abnormal. Artery stenosis was most common in the left middle cerebral artery (MCA) (34.4%). After multiple linear regression analysis was done, only MFV of right carotid siphon artery (CSA) (p = 0.060; r = - 0.493), MFV of left anterior cerebral artery (ACA) (p = 0.073; r = 0.332), MFV of left MCA (p = 0.065; r = 0.341), had significant correlation. The conclusion appears that the stroke risk score has moderate correlation with the degree of asymptomatic intracranial artery stenosis, especially with MFV of right CSA, left ACA and left MCA.