Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution.

Adetola Olubunmi Daramola,Mosebolatan Olatokunboh Odubanjo,Fred John Obiajulu,Nzechukwu Zimudo Ikeri,Adekunbiola Aina Fehintola Banjo

doi:10.1155/2015/742573

Adetola Olubunmi Daramola, Mosebolatan Olatokunboh Odubanjo + Show 3 more

Open Access

https://doi.org/10.1155/2015/742573

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Abstract

Background. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients. Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period. Methods. The findings obtained from FNAC of palpable breast lumps seen at the FNAC clinic of our department from January 2007 to December 2011 were retrieved and correlated with findings on histology of excisional biopsies. Results. A total of 1790 patients had FNAC of breast lumps during the 5-year period; 436 of them subsequently had biopsies. Our results compare favourably with the measures of test performance of the UK NHS Breast Screening Programme shown in brackets: absolute sensitivity 95.4% (>70%), complete sensitivity 99.2% (>90%), full specificity 88.9% (>65%), positive predictive value 99.6% (>99%), false-negative rate 0.8% (<4%), false-positive rate 0.4% (<0.5%), inadequate rate 3.2% (<15%), and suspicious rate 10.2% (<15%). Conclusion. Breast FNACs compare very well with histology of excisional biopsies and in experienced hands are extremely useful in the management of breast lumps. Further studies assessing the diagnostic accuracy of FNAC and cell blocks in our setting are recommended.

Highlights

Breast cancer is the commonest malignancy in women worldwide and the preoperative evaluation of breast lumps is an essential part of the management of breast lesions [1, 2]
Records of Fine-needle aspiration cytology (FNAC) results of palpable breast lumps seen at the FNAC clinic of the Department of Anatomic and Molecular Pathology of the Lagos University Teaching Hospital (LUTH) from 2007 to 2011 were retrieved from the database
FNAC was performed for all the cases using a 23 G needle attached to 20 mL disposable plastic syringes smeared on standard microscope glass slides, fixed with alcohol, and stained with Haematoxylin and Eosin (H&E), modified Giemsa, and Papanicolaou (Pap) stains

Summary

Introduction

Breast cancer is the commonest malignancy in women worldwide and the preoperative evaluation of breast lumps is an essential part of the management of breast lesions [1, 2]. The use of core needle biopsy in the management of palpable breast lumps in recent times has been increasing [3, 4]. Core needle biopsy is not without disadvantages These include a high cost (when compared with FNAC), long tissue processing time, patient discomfort such as pain and haematoma, and the risk of seeding of the tumor along the needle track [2, 5]. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period. Breast FNACs compare very well with histology of excisional biopsies and in experienced hands are extremely useful in the management of breast lumps. Further studies assessing the diagnostic accuracy of FNAC and cell blocks in our setting are recommended

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Conclusion