Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke

Abstract

Background: High levels of fibrinogen will increase the blood viscosity. Pulsatility index parameter intranscranial doppler can measure blood vessel resistance which influence by cerebral blood flow velocityand blood viscosity. This study has aim to find correlation between fibrinogen with PI in acute thromboticstroke patient.Method: A cross sectional design was used in this study. The samples were patient with acute ischemic strokein neurological ward Dr. Soetomo Hospital Surabaya from January 2019 to December 2020. Fibrinogenlevel was measured using clauss method. PI was calculated by peak systolic velocity, end diastolic velocityand mean vessel velocity, which were measured in middle cerebral artery.Result: This study involved 32 samples consisted 22 males and 10 females. Mean age of subjects was55.37 ± 10.55. The mean fibrinogen level is 356.95 ± 139.57. Mean MCA PI is 1.03 ±0.34. There is positivecorrelation with weak correlation strength between fibrinogen level with MCA PI in acute thrombotic strokepatients and statistically significant (p=0.024, r=0.398).Conclusion: There is a positive correlation between fibrinogen level with PI MCA in acute thromboticstroke.