Correlation between fetal right aortic arch and chromosome abnormality

Abstract

Objective To analyze the correlation between fetal right aortic arch and chromosome abnormality by ultrasound. Methods From January Jan 2009 to Dec 2014, nineteen cases with fetal right aortic arch were enrolled.They were all determined by chromosome karyotype analysis.The correlation of fetal right aortic arch and chromosome abnormalities detected by ultrasound were evaluated. Results Left lock, a U shaped vascular structure, were found in 15 cases.One case of fetal aortic arch was surrounded by a O shaped package.Three cases of right aortic arch showed fetal left artery catheter and brachiocephalic artery imaging branch.Echocardiography mainly for arterial catheter in three vessel trachea view did not show up.Artery catheter, in front of the trachea, did not form the vascular ring.Nineteen cases of right aortic arch were examined by fetal karyotype analysis.Three patients with trisomy 18-karyotype presented ventricular septal defect, single artium, three tricuspid atresia, pulmonary artery stenosis.Four cases with trisomy 18-karyotype presented ventricular septal defect, complete atrioventricular canal, single artium, double outlet right ventricle, pulmonary artery stenosis in atresia.Three cases with trisomy 21- karyotype showed single ventricle, single atrium.One case was with tetralogy of Fallot and one case with dextrocardia, aortic stenosis, accompanied by 22q11.2. Conclusion In prenatal ultrasound screening, we should pay attention to three vessels-trachea view on ultrasound image, which can improve the detection rate of right aortic arch.Fetal right aortic arch and trisomy 18-, trisomy 21-, chromosomal diseases are substantially correlated.Further analysis of chromosome karyotype is needed to exclude chromosomal lesions, so as to achieve the purpose of prenatal and postnatal care. Key words: Chromosome; Fetus; Musculoskeletal system; Ultrasound examination; Prenatal