Abstract
Objective To investigate the expression and the clinical significance of Survivin and cysteinyl aspartate-specific protease (Caspase)-3 in human sacral chordoma tissues.Methods The expression of Survivin and Caspase-3 was detected in 30 cases of human sacral chordoma tissues and 10 normal notochord tissues by using streptavidin biotin peroxidase (SP) immunohistochemistry.Results The positive expression rate of Survivin in chordoma was 70.0％,while none of 10 cases in the normal notochord tissues expressed Survivin,with significant difference between two groups (P ＜0.05).The positive rate of Survivin was correlated significantly with tumor invasion of the surrounding muscle and recurrence (P ＜ 0.05).The positive expression rate of Caspase-3 was significantly lower in chordoma (33.3％) than that in normal notochord tissues (90.0％),with significant difference between two groups (P ＜ 0.05).The positive rate of Caspase-3 was correlated significantly with tumor invasion of the surrounding muscle and recurrence (P ＜ 0.05).The expression of Survivin and VEGF was correlated negatively with each other (r =-0.463,P ＜ 0.05).Conclusion The high expression of Survivin in sacral chordoma,possibly through inhibition of Caspase-3 activity,may prevent apoptosis and promote tumor cell proliferation,which may play a significant role in cancer development,progression and prognosis. Key words: Sacrum; Chordoma; Survivin; Caspase-3
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